Ultimately, the timing of Allegra 120 depends on the individual’s symptoms, routine, and response to treatment. It's always best to follow a doctor’s guidance for when and how to take the medication to achieve the most effective relief with the fewest side effects. Furthermore, for individuals with chronic hives or nighttime itching, taking Allegra 120 at night can help reduce nocturnal itching and improve sleep quality, which in turn can enhance overall well-being. Taking Allegra 120 the night before can ensure that the medication is already active in the body when those symptoms begin.